| 評估類型 | 急性毒性 | 全身毒性 - 單次劑量 | 全身毒性 - 重複劑量 | 神經毒性 - 單次劑量 | 皮膚致敏 | 呼吸致敏 | 皮膚刺激 | 眼睛刺激 |
|---|---|---|---|---|---|---|---|---|
| 危害評估等級 |
資料不足
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資料不足
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資料不足
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資料不足
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資料不足
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資料不足
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資料不足
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危害診斷模組
危害診斷模組是由以下四種計算化學方法構成，所預測之毒性警示提供參考，仍須與其他資料綜合評估：
- 子結構警示
- 相似性警示
- 交叉參照
- 分類模型
| SMARTS 結構表示式 | 終點 | 資料來源 | 作者 | 期刊出處 |
|---|
物化特性
| 性質 | 數值 | 資料來源 |
|---|---|---|
| 沸點 |
100 °C
原文：212 °F at 760 mmHg
其他來源（2 筆）
|
CAMEO Chemicals |
| 熔點 |
0 °C
原文：32 °F
其他來源（2 筆）
|
CAMEO Chemicals |
| 蒸氣壓 |
3.1664 kPa
原文：23.75 [mmHg]
其他來源（2 筆）
|
Haz-Map, Information on Hazardous Chemicals and Occupational Diseases |
| 溶解度 |
Completely miscible
其他來源（3 筆）
|
DrugBank |
| 密度 |
0.995 g·cm⁻³
原文：0.9950 g/cu cm at 25 °C
其他來源（5 筆）
|
Hazardous Substances Data Bank (HSDB) |
| 分配係數 (LogP) | -1.38 | Human Metabolome Database (HMDB) |
資料來源：PubChem
安全替代物
安全替代物參考目前安全替代資料庫與軟體運作邏輯，分為以下三類：
- 系統透過美國環保署 ChemView 資料庫整理各化學物工業用途，結合美國環保署更安全化學物質， 建立個別化學品安全替代物清單。化學品可能具有多個工業用途，故系統採手風琴式展開清單， 點選「建議安全替代物」標籤即可展開表格。若用途較為廣泛（例：「商業用途」），清單內可能出現 更精確之工業用途（例：「溶劑」）的安全替代物。若無資訊，可參考「依工業用途（完整清單）」進行人工篩選。
- 依工業用途區分（完整清單）。此清單為整理工業用途較安全化學物，未必可直接替代本頁化學物質。 建議使用此頁籤右上方搜尋欄過濾工業用途再行篩選，例如「抗氧化劑」。資料來源： 美國環保署更安全化學物質成分清單 Safer Chemical Ingredients List
-
依結構相似性分類，需具備：
- 由結構相似性尋找具有相似官能基之化學物質（谷本相關係數 ≥ 0.8），功能可能相近。
- 由風險評估判定為較低風險之化學物質，如等級 3、等級 4，或資料不足（U）。
- 依實際案例探討。資料來源 OECD SAAT
系統依照子結構，列出風險等級為三級（可用、但可尋求更安全替代物）、四級（安全化學物質）、與資料不足（U、無足夠資料可供判別風險等級） 說明
下載：
SCIL（CSV格式）
SCIL（XLSX格式）
ZeroPM PFAS（CSV格式）
ZeroPM PFAS（XLSX格式）
SUBSPORT+ 案例替代方案（CSV格式）
SUBSPORT+ 案例替代方案（XLSX格式）
| 名稱 | CAS | 工業用途 | 安全性 | 註解 |
|---|
此化學物不在 ZeroPM PFAS 替代方案資料庫中。
SUBSPORT+ 替代案例
SUBSPORT+ 案例資料庫中與本化學物相關的實際替代案例（英文記錄）。
| 案例 | 本化學物的角色 | 替代方案 | 產業 | 功能 | 實施狀況 | 替代理由 |
|---|---|---|---|---|---|---|
| Substitution of toluene and butan-1-ol in inks for the printing of plastic bags | 作為替代品 |
|
Manufacture of rubber products Manufacture of plastics products, including compounding and conversion | Solvent Other | Full capacity — 2007 Spain | other toxic effects ecotoxicity physical hazards |
| Substitution of isopropanol, 2-methylpropan-1-ol and heptane in the cleaning of printing rolls | 作為替代品 |
|
Manufacture of rubber products Manufacture of plastics products, including compounding and conversion | Cleaning agent | Full capacity — 2007 Spain | other toxic effects ecotoxicity physical hazards |
| Substitution of tetrachloroethylene used in dry clean systems by a professional wet clean system for the garment care industry | 作為替代品 |
|
Other | Friction agent | Full capacity — 2003 USA | CMR ecotoxicity |
| Different ways to phase out halocarbons like dichloromethane in various applications. | 作為替代品 |
|
Scientific research and development Building and construction work General manufacturing, e.g. machinery, equipment, vehicles, other transport equipment Manufacture of computer, electronic and optical products, electrical equipment Manufacture of fabricated metal products, except machinery and equipment Manufacture of basic metals, including alloys Manufacture of plastics products, including compounding and conversion Manufacture of rubber products | Solvent | Partial capacity — Sweden | CMR physical hazards |
| Substitution of a neurotoxic solvent that contained acetates and acetone used in the cleaning of metal parts | 被替代 |
|
General manufacturing, e.g. machinery, equipment, vehicles, other transport equipment | Solvent | In use — 2011 en España | neurotoxicant |
| Substitution of plastic paints by mineral-based paints in Metro Madrid | 作為替代品 |
|
Manufacture of bulk, large scale chemicals (including petroleum products) Building and construction work | Dye | Full capacity — 2007 Spain | CMR |
| Substitution of plastic paints by mineral-based paints in Metro Madrid | 作為替代品 |
|
Other | Reducing agent | Germany | CMR |
| Aqueous solution combined with ultrafiltration as an alternative to 4-methylpentan-2-one (MIBK) in purification of penicillin. | 作為替代品 |
|
Manufacture of bulk, large scale chemicals (including petroleum products) Manufacture of fine chemicals Health services Scientific research and development | Processing aid | Full capacity — 1990 Denmark | skin/respiratory sensitizing |
| Substitution of perchloroethylene in dry cleaners’ shops by “wet cleaning” systems. | 作為替代品 |
|
Other | Cleaning agent | Full capacity — 2008 | CMR ecotoxicity |
| Cleaning of lorry and van drum brakes by heated tap water | 作為替代品 |
|
General manufacturing, e.g. machinery, equipment, vehicles, other transport equipment Other | Solvent | In use — 2003 in Germany | other toxic effects physical hazards CMR |
| The cleaning of car brakes by hot-water low-pressure spray washer | 作為替代品 |
|
General manufacturing, e.g. machinery, equipment, vehicles, other transport equipment | Cleaning agent | In use — 2007 in Germany | other toxic effects physical hazards CMR |
| Cleaning of wafer frames with brushing machines using tap water | 作為替代品 |
|
General manufacturing, e.g. machinery, equipment, vehicles, other transport equipment Manufacture of computer, electronic and optical products, electrical equipment | Solvent | In use — 2005 in Germany | other toxic effects physical hazards CMR |
| Components cleaning with deionised water | 作為替代品 |
|
General manufacturing, e.g. machinery, equipment, vehicles, other transport equipment | Cleaning agent | In use — 2004 in Germany | other toxic effects |
| Pressurised water as alternative to cleaning of rotary screen in the textile sector | 作為替代品 |
|
Manufacture of textiles, leather, fur | Cleaning agent Other | Full capacity — 2000 | CMR skin/respiratory sensitizing |
| Substitution of a cleaning agent containing sodium hypochlorate used for disinfection | 作為替代品 |
|
Building and construction work Other | Cleaning agent | Full capacity — 2009, Spain | skin/respiratory sensitizing ecotoxicity |
| Alternatives to Toxic, VOC, Ozone Depleting and Global Warming Energised Electrical Equipment Cleaners | 作為替代品 |
|
Scientific research and development | Cleaning agent | Full capacity | CMR skin/respiratory sensitizing ecotoxicity |
| Enzymatic processes versus chemical processes in the preparation of 6-aminopenicillanic acid | 作為替代品 |
|
Health services Scientific research and development | Other | In use | CMR neurotoxicant other toxic effects ecotoxicity |
| Substitution of a hydrocarbon-based anti-adherent used in industrial welding | 作為替代品 |
|
Manufacture of basic metals, including alloys Manufacture of fabricated metal products, except machinery and equipment General manufacturing, e.g. machinery, equipment, vehicles, other transport equipment | Other | Full capacity — 2010, Spain | CMR |
| Electrochemical activation of saline aqueous solution as source for alternative disinfectant in Moscow hospital | 作為替代品 |
|
Other | Cleaning agent | In use — Russia | skin/respiratory sensitizing ecotoxicity |
| Substitution of naphtha and hexamethylene diisocyanate in polyurethane-based paints | 作為替代品 |
|
Manufacture of fabricated metal products, except machinery and equipment General manufacturing, e.g. machinery, equipment, vehicles, other transport equipment Building and construction work Other | Solvent | Full capacity — 2009 in Spain | other toxic effects skin/respiratory sensitizing |
| Environmental-friendly textile cleaning using wet cleaning or carbon dioxide | 作為替代品 |
|
Other | Other | In use | CMR |
| Phase-out of a brightening agent containing traces of NPEOs | 作為替代品 |
|
Manufacture of textiles, leather, fur | Other | In use — Year: 2015, Country: China | ecotoxicity other reasons |
| Substitution of a chemical based on C6-fluorocarbons with a PFC-free chemical in the manufacture of water-repellent textiles | 作為替代品 |
|
Manufacture of textiles, leather, fur | Other | In use — Year: 2016 | ecotoxicity other reasons |
OECD SAAT 替代方案案例
OECD SAAT 案例完整清單（不隨化學物過濾）。
| 實例探討名稱 | 連結 | 發佈日期 | 發佈單位 | 相關產品 | 敘述 |
|---|