Searching, Assessment, and Screening system for safer alternative chemicals

Searching, assessment, and screening system for safter alternative chemicals, SAS

    e.g. Benzene, DEHP, 71-43-2, BPA, phthalate

    Boric acid [Also CAS RN: 11113-50-1]

    Chemical structure of PubChem CID 7628

    Risk Level Help

    Chemical Substance Information

    • PubChem CID: 7628
    • CAS: 10043-35-3

    Hazard Assessment Overview Help

    Hazard Sunburst Chart Legend

    Hazard Assessment Summary Table Help CSV format XLSX format
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    Assessment Type Carcinogenicity Mutagenicity Reproductive Toxicity Developmental Toxicity Endocrine Disruption
    Hazard Assessment Level
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    Assessment Type Acute Toxicity Systemic Toxicity - Single Dose Systemic Toxicity - Repeated Dose Neurotoxicity - Single Dose Skin Sensitization Respiratory Sensitization Skin Irritation Eye Irritation
    Hazard Assessment Level
    Insufficient data
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    Assessment Type Acute Aquatic Toxicity Chronic Aquatic Toxicity
    Hazard Assessment Level
    Insufficient data
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    Assessment Type Persistence Bioaccumulation
    Hazard Assessment Level
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    Assessment Type Reactivity Flammability
    Hazard Assessment Level
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    Hazard Diagnostic Modules

    The Hazard Diagnostic Module consists of the following four computational chemistry methods. The predicted toxicity alerts are for reference only and should be evaluated together with other available data.

    1. Substructure Alerts
    2. Similarity Alerts
    3. Read-Across
    4. Classification Models

    No SMILES structure is available for this chemical; substructure alert calculation cannot be performed.
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    Safer Alternatives

    Safer alternatives are referenced from current safer chemical databases and software logic, divided into the following three categories:

    1. The system compiles industrial uses of chemicals from the US EPA ChemView database and integrates them with the US EPA Safer Chemical Ingredients to create a safer alternatives list for each chemical. Chemicals may have multiple industrial uses, so the system uses an accordion-style display. Click the 'Suggested Safer Alternatives' tab to expand the table. If the use is broad (e.g., 'Commercial use'), the list may include more specific uses (e.g., 'Solvent'). If no information is available, refer to 'By Industrial Use (Full List)' for manual filtering.
    2. Categorized by industrial use (full list). This list contains safer chemicals for industrial uses, not necessarily replacements for the chemical on this page. You may filter by industrial use via the search bar at the top right of this tab, e.g., filter by 'Antioxidants'. Source: Safer Chemical Ingredients List
    3. Categorized by structural similarity, requiring:
      • Find chemicals with similar functional groups based on structural similarity (Tanimoto coefficient ≥ 0.8), likely having similar functions.
      • Chemicals identified as lower risk by risk assessment, such as level 3, level 4, or insufficient data.
      Practical substitution feasibility still requires domain knowledge and reference to physicochemical properties. For insufficient data (U), it means current hazard and risk assessment information is limited; thus, selection should be cautious and toxicology studies should be reviewed.
    4. Based on real-world case studies. Source: OECD SAAT

    Based on substructure, the system lists chemicals with risk levels 3 (usable but safer alternatives may be sought), 4 (safer chemicals), or insufficient data (U: not enough data to determine risk level). Information

    Download: SCIL (CSV) SCIL (XLSX) ZeroPM PFAS (CSV) ZeroPM PFAS (XLSX) SUBSPORT+ case alternatives (CSV) SUBSPORT+ case alternatives (XLSX)
    Name CAS Industrial Use Safety Notes
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    This chemical is not listed in the ZeroPM PFAS alternative assessment database.
    SUBSPORT+ substitution case stories

    Real-world substitution cases involving this chemical, from the SUBSPORT+ case story database (English records).

    Case Role of this chemical Alternative Sector Function Implementation Reason for substitution
    Playing dough manufactured without hazardous chemicals, and is eatable Substituted
    • Wheat Flour, Sugar, Whole Egg Powder, Palm Oil, Wheat Starch, Modified Starch, Glucose Syrup, Maltodextrin, Milk Protein, Flavourings and Colouring: Beetroot Red, Curcumin and E 133.
    Non-chemical alternative The ingredients of conventional modelling dough are often: boric acid, sulphates, benzoates, borax, fungicides and other preservatives, colorants and fragrances, emulsifiers, lubricants, binders, hardeners or moisturizers, and many other chemicals. Because the manufacturers have no obligation to list the ingredients on the packaging, they are unknown to the end-users. The 'Yummy playing dough' contains: Wheat Flour, Sugar, Whole Egg Powder, Palm Oil, Wheat Starch, Modified Starch, Glucose Syrup, Maltodextrin, Milk Protein, Flavourings and Colouring: Beetroot Red, Curcumin and E 133 (since April 2010)     		Manufacture of plastics products, including compounding and conversion Other Other Full capacity — 2007 Germany, since the 18 countries CMR other toxic effects
    A wood treatment product completely free from heavy metals, halogenated and phosphorus compounds. Gives flame retardant properties and protects against rot fungus. Substituted
    • Inorganic silicon polymer
    • Organic acid
    		Manufacture of wood and wood products Manufacture of furniture Building and construction work Biocide Flame retardant In use — Sweden, Finland, 2011 CMR PBT other toxic effects ecotoxicity
    Substitutions performed at the National Centre for Health Data and Disease Control in Denmark (SSI) Substituted
    • Acetic acid (64-19-7)
    • Sodium hydroxide (1310-73-2)
    • Nigrosin (acid black 2) (8005-03-6)
    		Health services Other Cleaning agent Dye In use CMR ED neurotoxicant
    Substitution of boric acid by lactic acid as biocide in cooling lubricants Substituted
    • Lactic acid (50-21-5)
    		Manufacture of computer, electronic and optical products, electrical equipment General manufacturing, e.g. machinery, equipment, vehicles, other transport equipment Other Biocide Lubricating agent In use CMR ED
    Substitution of chemical products used for radiography fixation and developing with a digital system Substituted Non-chemical alternative Digitised radiography system, consisting of a display of digital medical imaging for diagnostic use with a range of software called RAIM (Radiological Archive and Image Management). Health services Photochemical X-Ray Absorber Full capacity — 2004, Spain CMR skin/respiratory sensitizing other toxic effects ecotoxicity
    Substitution of chromium trioxide and nickel in the electroplating of sanitary appliances by a nickel free trivalent chromium process to prevent nickel leaching into drinking water Used as alternative
    • Boric acid (10043-35-3)
    • Chromium sulfate (10101-53-8)
    • Copper sulfate pentahydrate (7758-98-7)
    		Other Plating agent In use CMR skin/respiratory sensitizing other toxic effects ecotoxicity physical hazards
    Substitution of chromium trioxide and nickel in the electroplating of sanitary appliances by a nickel free trivalent chromium process to prevent nickel leaching into drinking water Used as alternative
    • Boric acid (10043-35-3)
    • Chromium sulfate (10101-53-8)
    • Dicopper oxide (1317-39-1)
    • Tin methane sulfonic acid (53408-94-9)
    		Other Plating agent Pilot study CMR other toxic effects ecotoxicity physical hazards
    Substitution of chromium trioxide in the electroplating of sanitary appliances by a trivalent chromium process Used as alternative
    • Boric acid (10043-35-3)
    • Chromium sulfate (10101-53-8)
    		Other Plating agent In use CMR skin/respiratory sensitizing other toxic effects ecotoxicity physical hazards
    Substitution of boric acid in metal processing Substituted Non-chemical alternative Switching to alternative technology which allows surface treatment by mechanical-abrasive means. Flywheel and clutch pressure plate grinder with standard equipment. General manufacturing, e.g. machinery, equipment, vehicles, other transport equipment Lubricating agent Other In use CMR
    OECD SAAT alternative case studies

    Full list of OECD SAAT case studies (not filtered by chemical).

    Case Study Name Link Publish Date Publishing Organization Related Products Description

    Contents

    1. Risk Level
    2. Chemical Substance Information
    3. Hazard Assessment Overview
    4. Hazard Assessment Summary Table
    5. Hazard Diagnostic Modules
    6. Safer Alternatives