危害診斷模組
危害診斷模組是由以下四種計算化學方法構成，所預測之毒性警示提供參考，仍須與其他資料綜合評估：
- 子結構警示
- 相似性警示
- 交叉參照
- 分類模型
| Smarts | Endpoint | Source | Author | Journal |
|---|
安全替代物
安全替代物參考目前安全替代資料庫與軟體運作邏輯，分為以下三類：
- 系統透過美國環保署 ChemView 資料庫整理各化學物工業用途，結合美國環保署更安全化學物質， 建立個別化學品安全替代物清單。化學品可能具有多個工業用途，故系統採手風琴式展開清單， 點選「建議安全替代物」標籤即可展開表格。若用途較為廣泛（例：「商業用途」），清單內可能出現 更精確之工業用途（例：「溶劑」）的安全替代物。若無資訊，可參考「依工業用途（完整清單）」進行人工篩選。
- 依工業用途區分（完整清單）。此清單為整理工業用途較安全化學物，未必可直接替代本頁化學物質。 建議使用此頁籤右上方搜尋欄過濾工業用途再行篩選，例如「抗氧化劑」。資料來源： 美國環保署更安全化學物質成分清單 Safer Chemical Ingredients List
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依結構相似性分類，需具備：
- 由結構相似性尋找具有相似官能基之化學物質（谷本相關係數 ≥ 0.8），功能可能相近。
- 由風險評估判定為較低風險之化學物質，如等級 3、等級 4，或資料不足（U）。
- 依實際案例探討。資料來源 OECD SAAT
系統依照子結構，列出風險等級為三級（可用、但可尋求更安全替代物）、四級（安全化學物質）、與資料不足（U、無足夠資料可供判別風險等級） 說明
下載：
SCIL（CSV格式）
SCIL（XLSX格式）
ZeroPM PFAS（CSV格式）
ZeroPM PFAS（XLSX格式）
SUBSPORT+ 案例替代方案（CSV格式）
SUBSPORT+ 案例替代方案（XLSX格式）
| 名稱 | CAS | 工業用途 | 安全性 | 註解 |
|---|
此化學物不在 ZeroPM PFAS 替代方案資料庫中。
SUBSPORT+ 替代案例
SUBSPORT+ 案例資料庫中與本化學物相關的實際替代案例（英文記錄）。
| 案例 | 本化學物的角色 | 替代方案 | 產業 | 功能 | 實施狀況 | 替代理由 |
|---|---|---|---|---|---|---|
| Different ways to phase out halocarbons like dichloromethane in various applications. | 被替代 |
|
Scientific research and development Building and construction work General manufacturing, e.g. machinery, equipment, vehicles, other transport equipment Manufacture of computer, electronic and optical products, electrical equipment Manufacture of fabricated metal products, except machinery and equipment Manufacture of basic metals, including alloys Manufacture of plastics products, including compounding and conversion Manufacture of rubber products | Solvent | Partial capacity — Sweden | CMR physical hazards |
| Practical guide for the substitution of hazardous chemicals by less harmful substances in industrial facilities. | 被替代 | 未說明 | Other | Other | CMR neurotoxicant skin/respiratory sensitizing physical hazards | |
| Dimethyl sulfoxide as alternative solvent | 被替代 | 未說明 | Manufacture of bulk, large scale chemicals (including petroleum products) Manufacture of fine chemicals Manufacture of rubber products Manufacture of plastics products, including compounding and conversion Building and construction work | Solvent | In use | CMR sensitizing |
| Infrared paint stripper used as alternative to chemical stripping | 被替代 | 非化學品替代 Infrared paint stripper | Building and construction work | Cleaning agent | In use — 2010, Romania | CMR |
| Substitution of dichloromethane in the analysis of pesticide residue | 被替代 |
|
Agriculture, forestry, fishery Manufacture of food products Scientific research and development | Solvent | ecotoxicity physical hazards | |
| Use of carbon dioxide as alternative for caffeine extraction | 被替代 |
|
Manufacture of food products | Other | In use | CMR neurotoxicant |
| Facade cleaning using dry ice blasting for monument restoration in Prague | 被替代 |
|
Building and construction work | Cleaning agent | In use — Prague | CMR |
| Paint stripping of dashboards | 被替代 |
|
General manufacturing, e.g. machinery, equipment, vehicles, other transport equipment | Solvent | In use — 2005 in Germany | CMR |
| Pressurised water as alternative to cleaning of rotary screen in the textile sector | 被替代 |
|
Manufacture of textiles, leather, fur | Cleaning agent Other | Full capacity — 2000 | CMR skin/respiratory sensitizing |
| Extraction of Active Pharmaceutical Ingredients (API’s) and other active organic compounds with Supercritical Carbon Dioxide. | 被替代 |
|
Health services Other | Other | Full capacity | CMR physical hazards skin/respiratory sensitizing other toxic effects |
| Enzymatic processes versus chemical processes in the preparation of 6-aminopenicillanic acid | 被替代 |
|
Health services Scientific research and development | Other | In use | CMR neurotoxicant other toxic effects ecotoxicity |
| Substitution of a hydrocarbon-based anti-adherent used in industrial welding | 被替代 |
|
Manufacture of basic metals, including alloys Manufacture of fabricated metal products, except machinery and equipment General manufacturing, e.g. machinery, equipment, vehicles, other transport equipment | Other | Full capacity — 2010, Spain | CMR |
| Alternative to dichloromethane in graffiti and paint stripping | 被替代 |
|
Building and construction work Other | Other | In use | CMR |
| Replacement of dichloromethane, trichloroethane, acetone and toluene by dibasic esters as cleaning solvent in a yacht company | 被替代 |
|
Agriculture, forestry, fishery Other | Cleaning agent Solvent | In use | CMR skin/respiratory sensitizing ecotoxicity physical hazards |
| Cleaning after polymerisation of acrylate plastic. | 被替代 | 非化學品替代 Pressurised hot water. Ethyl acetate is now only used, but in minor amounts. | Manufacture of rubber products Manufacture of plastics products, including compounding and conversion | Cleaning agent Other | In use — 2004 Denmark | CMR skin/respiratory sensitizing physical hazards neurotoxicant |
| Ethyl lactate and methyl soyate as bio based alternatives to chlorinated and other petroleum based solvents | 被替代 |
|
Other | Cleaning agent Plating agent Solvent | In use | physical hazards neurotoxicant CMR ED skin/respiratory sensitizing |
| Substitution of methylene chloride as cleaning agent in a company producing construction chemicals | 被替代 |
|
Building and construction work | Cleaning agent | Pilot study | CMR |
OECD SAAT 替代方案案例
OECD SAAT 案例完整清單（不隨化學物過濾）。
| 實例探討名稱 | 連結 | 發佈日期 | 發佈單位 | 相關產品 | 敘述 |
|---|