Searching, Assessment, and Screening system for safer alternative chemicals

Searching, assessment, and screening system for safer alternative chemicals, GreenN (Green Next)

    e.g.

    disodium tetraborate, anhydrous; boric acid, disodium salt [1]tetraboron disodium heptaoxide, hydrate [2]orthoboric acid, sodium salt [3]

    Chemical structure of PubChem CID 10219853

    Risk Level Help

    Chemical Substance Information

    • PubChem CID: 10219853
    • CAS: 1330-43-4
    • EC NO: 215-540-4
    • Safety Data Sheet: Link
    • SMILES: B1(OB2OB(OB(O1)O2)[O-])[O-].[Na+].[Na+]

    Hazard Assessment Overview Help

    Hazard Sunburst Chart Legend

    Hazard Assessment Summary Table Help CSV format XLSX format
    Reset


    Assessment Type Carcinogenicity Mutagenicity Reproductive Toxicity Developmental Toxicity Endocrine Disruption
    Hazard Assessment Level
    High
    High
    Insufficient data
    for classification
    Insufficient data
    for classification
    Insufficient data
    for classification
    Loading
    Assessment Type Acute Toxicity Systemic Toxicity - Single Dose Systemic Toxicity - Repeated Dose Neurotoxicity - Single Dose Skin Sensitization Respiratory Sensitization Skin Irritation Eye Irritation
    Hazard Assessment Level
    Insufficient data
    for classification
    Insufficient data
    for classification
    Insufficient data
    for classification
    Insufficient data
    for classification
    Insufficient data
    for classification
    Insufficient data
    for classification
    Insufficient data
    for classification
    Insufficient data
    for classification
    Loading
    Assessment Type Acute Aquatic Toxicity Chronic Aquatic Toxicity
    Hazard Assessment Level
    Insufficient data
    for classification
    Insufficient data
    for classification
    Loading
    Assessment Type Persistence Bioaccumulation
    Hazard Assessment Level
    Insufficient data
    for classification
    Insufficient data
    for classification
    Assessment Type Reactivity Flammability
    Hazard Assessment Level
    Insufficient data
    for classification
    Insufficient data
    for classification
    Loading

    Hazard Diagnostic Modules

    The Hazard Diagnostic Module consists of the following four computational chemistry methods. The predicted toxicity alerts are for reference only and should be evaluated together with other available data.

    1. Substructure Alerts
    2. Similarity Alerts
    3. Read-Across
    4. Classification Models

    SMARTS Pattern Endpoint Source Author Journal Reference
    Loading
    Loading
    Loading

    Physical and Chemical Properties

    Property Value Source
    Boiling Point 1575 °C
    As reported: 2867 °F (decomposes)
    Other sources (1)
    • 1,575 °C (decomposes) — Hazardous Substances Data Bank (HSDB)
    		The National Institute for Occupational Safety and Health (NIOSH)
    Melting Point 171 °C
    As reported: Between 171 °C and 175 °C with decomposition
    Other sources (3)
    • 743 °C — Hazardous Substances Data Bank (HSDB)
    • 742 °C — ILO-WHO International Chemical Safety Cards (ICSCs)
    • 741.111 °C (1366 °F) — The National Institute for Occupational Safety and Health (NIOSH)
    		EU Food Improvement Agents
    Vapor Pressure Negligible at 20 °C
    Other sources (1)
    • 0 mmHg (approx) — The National Institute for Occupational Safety and Health (NIOSH)
    		Hazardous Substances Data Bank (HSDB)
    Solubility Water solubility: 3.1% at 25 °C; 2.5% at 20 °C
    Other sources (3)
    • Solubility at 25 °C: 16.7% in methanol; 30% in ethylene glycol; 40.6 g/L in formamide — Hazardous Substances Data Bank (HSDB)
    • Solubility in water, g/100ml at 20 °C: 2.56 — ILO-WHO International Chemical Safety Cards (ICSCs)
    • 4% — The National Institute for Occupational Safety and Health (NIOSH)
    		Hazardous Substances Data Bank (HSDB)
    Density 2.4 g·cm⁻³
    As reported: Relative density (water = 1): 2.4
    Other sources (3)
    • 2.367 — Hazardous Substances Data Bank (HSDB)
    • White crystals or powder, odorless; density: 1.73 20 °C/4 °C; loses water of crystallization when heated, with melting between 75 and 320 °C; fuses to a glassy mass at red heat (borax glass); effloresces slightly in warm dry air; soluble in water, glycerol; insoluble in alcohol /Sodium tetraborate decahydrate/ — Hazardous Substances Data Bank (HSDB)
    • 2.37 — The National Institute for Occupational Safety and Health (NIOSH)
    		ILO-WHO International Chemical Safety Cards (ICSCs)

    Source: PubChem

    Safer Alternatives

    Safer alternatives are referenced from current safer chemical databases and software logic, divided into the following three categories:

    1. The system compiles industrial uses of chemicals from the US EPA ChemView database and integrates them with the US EPA Safer Chemical Ingredients to create a safer alternatives list for each chemical. Chemicals may have multiple industrial uses, so the system uses an accordion-style display. Click the 'Suggested Safer Alternatives' tab to expand the table. If the use is broad (e.g., 'Commercial use'), the list may include more specific uses (e.g., 'Solvent'). If no information is available, refer to 'By Industrial Use (Full List)' for manual filtering.
    2. Categorized by industrial use (full list). This list contains safer chemicals for industrial uses, not necessarily replacements for the chemical on this page. You may filter by industrial use via the search bar at the top right of this tab, e.g., filter by 'Antioxidants'. Source: Safer Chemical Ingredients List
    3. Categorized by structural similarity, requiring:
      • Find chemicals with similar functional groups based on structural similarity (Tanimoto coefficient ≥ 0.8), likely having similar functions.
      • Chemicals identified as lower risk by risk assessment, such as level 3, level 4, or insufficient data.
      Practical substitution feasibility still requires domain knowledge and reference to physicochemical properties. For insufficient data (U), it means current hazard and risk assessment information is limited; thus, selection should be cautious and toxicology studies should be reviewed.
    4. Based on real-world case studies. Source: OECD SAAT

    Based on substructure, the system lists chemicals with risk levels 3 (usable but safer alternatives may be sought), 4 (safer chemicals), or insufficient data (U: not enough data to determine risk level). Information

    Download: CSV format XLSX format
    Name CAS Industrial Use Safety Risk Level Data Source Notes

    Download: CSV format XLSX format
    Name CAS Industrial Use Safety Risk Level Data Source Notes

    Download: CSV format XLSX format
    Name CAS Industrial Use Safety Risk Level Data Source Notes

    Download: CSV format XLSX format
    Name CAS Industrial Use Safety Risk Level Data Source Notes

    Download: CSV format XLSX format
    Name CAS Industrial Use Safety Risk Level Data Source Notes

    Download: CSV format XLSX format
    Name CAS Industrial Use Safety Risk Level Data Source Notes
    Download: SCIL (CSV) SCIL (XLSX) ZeroPM PFAS (CSV) ZeroPM PFAS (XLSX) SUBSPORT+ case alternatives (CSV) SUBSPORT+ case alternatives (XLSX)
    Name CAS Industrial Use Safety Notes
    Loading
    This chemical is not listed in the ZeroPM PFAS alternative assessment database.
    SUBSPORT+ substitution case stories

    Real-world substitution cases involving this chemical, from the SUBSPORT+ case story database (English records).

    Case Role of this chemical Alternative Sector Function Implementation Reason for substitution
    Playing dough manufactured without hazardous chemicals, and is eatable Substituted
    • Wheat Flour, Sugar, Whole Egg Powder, Palm Oil, Wheat Starch, Modified Starch, Glucose Syrup, Maltodextrin, Milk Protein, Flavourings and Colouring: Beetroot Red, Curcumin and E 133.
    Non-chemical alternative The ingredients of conventional modelling dough are often: boric acid, sulphates, benzoates, borax, fungicides and other preservatives, colorants and fragrances, emulsifiers, lubricants, binders, hardeners or moisturizers, and many other chemicals. Because the manufacturers have no obligation to list the ingredients on the packaging, they are unknown to the end-users. The 'Yummy playing dough' contains: Wheat Flour, Sugar, Whole Egg Powder, Palm Oil, Wheat Starch, Modified Starch, Glucose Syrup, Maltodextrin, Milk Protein, Flavourings and Colouring: Beetroot Red, Curcumin and E 133 (since April 2010)     		Manufacture of plastics products, including compounding and conversion Other Other Full capacity — 2007 Germany, since the 18 countries CMR other toxic effects
    Substituting Methanol and Borax in gold jewellery production. Substituted
    • Acetone (67-64-1)
    • Hydrogen (1333-74-0)
    		Manufacture of fabricated metal products, except machinery and equipment General manufacturing, e.g. machinery, equipment, vehicles, other transport equipment Other In use skin/respiratory sensitizing other toxic effects
    Substituting Borax for gem stone protection in gold jewellery production. Substituted Non-chemical alternative Cabinet laser welding Manufacture of fabricated metal products, except machinery and equipment General manufacturing, e.g. machinery, equipment, vehicles, other transport equipment Other In use other toxic effects
    OECD SAAT alternative case studies

    Full list of OECD SAAT case studies (not filtered by chemical).

    Case Study Name Link Publish Date Publishing Organization Related Products Description

    Contents

    1. Risk Level
    2. Chemical Substance Information
    3. Hazard Assessment Overview
    4. Hazard Assessment Summary Table
    5. Hazard Diagnostic Modules
    6. Safer Alternatives